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      <title>Why Is Gout on the Rise?</title>
      <description><![CDATA[<p>Drs Ken Saag and Hyon Choi examine the rising burden of gout, key population risk factors, medication effects, and opportunities to close persistent treatment gaps.</p><p>Relevant disclosures can be found with the episode show notes on Medscape <a href="https://www.medscape.com/ca8/p04/podcast-gout-s1-ep3-2026a1000qek" rel="noopener noreferrer">https://www.medscape.com/ca8/p04/podcast-gout-s1-ep3-2026a1000qek</a>. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.</p><p><strong>Resources</strong></p><p>Gout and Pseudogout <a href="https://emedicine.medscape.com/article/329958-overview" rel="noopener noreferrer">https://emedicine.medscape.com/article/329958-overview</a></p><p>Global, Regional, and National Burden of Gout, 1990-2020, and Projections to 2050: A Systematic Analysis of the Global Burden of Disease Study 2021 <a href="https://pubmed.ncbi.nlm.nih.gov/38996590/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/38996590/</a></p><p>Trends in Prevalence of Gout Among US Asian Adults, 2011-2018 <a href="https://pubmed.ncbi.nlm.nih.gov/37083663/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/37083663/</a></p><p>Rheumatoid Arthritis (RA) <a href="https://emedicine.medscape.com/article/331715-overview" rel="noopener noreferrer">https://emedicine.medscape.com/article/331715-overview</a></p><p>Gout Management in Patients With CKD: A Review <a href="https://pubmed.ncbi.nlm.nih.gov/40609855/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/40609855/</a></p><p>Dietary and Lifestyle-Centered Approach in Gout Care and Prevention <a href="https://pubmed.ncbi.nlm.nih.gov/34196878/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/34196878/</a></p><p>Impact of Alcohol Consumption on Hyperuricemia and Gout: A Systematic Review and Meta-analysis <a href="https://pubmed.ncbi.nlm.nih.gov/40463472/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/40463472/</a></p><p>Beer, Liquor, and Wine Consumption and Serum Uric Acid Level: The Third National Health and Nutrition Examination Survey <a href="https://pubmed.ncbi.nlm.nih.gov/15593346/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/15593346/</a></p><p>Alcohol Consumption as a Trigger of Recurrent Gout Attacks <a href="https://pubmed.ncbi.nlm.nih.gov/16945617/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/16945617/</a></p><p>Effects of Dietary Factors on Hyperuricaemia and Gout: A Systematic Review and Meta-analysis of Observational Studies <a href="https://pubmed.ncbi.nlm.nih.gov/39289820/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/39289820/</a></p><p>Is There a Role for Cherries in the Management of Gout? <a href="https://pubmed.ncbi.nlm.nih.gov/31205513/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/31205513/</a></p><p>Cherry Consumption and Decreased Risk for Recurrent Gout Attacks <a href="https://pubmed.ncbi.nlm.nih.gov/23023818/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/23023818/</a></p><p>Lowering and Raising Serum Urate Levels: Off-Label Effects of Commonly Used Medications <a href="https://pubmed.ncbi.nlm.nih.gov/35787862/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/35787862/</a></p><p>Environmental Triggers of Hyperuricemia and Gout <a href="https://pubmed.ncbi.nlm.nih.gov/36333002/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/36333002/</a></p><p>Elevated Blood Lead Levels Associated With Illicitly Distilled Alcohol—Alabama, 1990-1991 <a href="https://pubmed.ncbi.nlm.nih.gov/1565093/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/1565093/</a></p><p>SGLT2 Inhibitors vs Sulfonylureas for Gout Prevention Among Patients With Type 2 Diabetes Receiving Metformin <a href="https://pubmed.ncbi.nlm.nih.gov/38619822/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/38619822/</a></p><p>Newer Glucose-Lowering Drugs and Risk for Gout: A Network Meta-Analysis of Randomized Outcomes Trials <a href="https://pubmed.ncbi.nlm.nih.gov/38796335/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/38796335/</a></p><p>Asymptomatic Hyperuricemia. Risks and Consequences in the Normative Aging Study <a href="https://pubmed.ncbi.nlm.nih.gov/3826098/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/3826098/</a></p><p>Serum Urate and Recurrent Gout <a href="https://pubmed.ncbi.nlm.nih.gov/38319333/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/38319333/</a></p><p>Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients With Gout <a href="https://pubmed.ncbi.nlm.nih.gov/35916846/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/35916846/</a></p><p>Cardiovascular Safety of Febuxostat or Allopurinol in Patients With Gout <a href="https://pubmed.ncbi.nlm.nih.gov/29527974/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/29527974/</a></p><p>Trends in Gout and Rheumatoid Arthritis Hospitalizations in the United States, 1993-2011 <a href="https://pubmed.ncbi.nlm.nih.gov/27272587/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/27272587/</a></p><p>The Design of a Randomized Controlled Active Comparator Strategy Trial for Gout: Treat to Target Serum Urate Vs Treat to Avoid Symptoms <a href="https://pubmed.ncbi.nlm.nih.gov/40126890/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/40126890/</a></p><br/> <p>Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.</p>]]></description>
      <pubDate>Tue, 6 Oct 2026 14:16:59 +0000</pubDate>
      <author>medscapepodcasts@webmd.net (Dr Kenneth Saag, Dr Hyon K. Choi)</author>
      <link>https://www.medscape.com/ca8/p04/podcast-gout-s1-ep3-2026a1000qek</link>
      <content:encoded><![CDATA[<p>Drs Ken Saag and Hyon Choi examine the rising burden of gout, key population risk factors, medication effects, and opportunities to close persistent treatment gaps.</p><p>Relevant disclosures can be found with the episode show notes on Medscape <a href="https://www.medscape.com/ca8/p04/podcast-gout-s1-ep3-2026a1000qek" rel="noopener noreferrer">https://www.medscape.com/ca8/p04/podcast-gout-s1-ep3-2026a1000qek</a>. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.</p><p><strong>Resources</strong></p><p>Gout and Pseudogout <a href="https://emedicine.medscape.com/article/329958-overview" rel="noopener noreferrer">https://emedicine.medscape.com/article/329958-overview</a></p><p>Global, Regional, and National Burden of Gout, 1990-2020, and Projections to 2050: A Systematic Analysis of the Global Burden of Disease Study 2021 <a href="https://pubmed.ncbi.nlm.nih.gov/38996590/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/38996590/</a></p><p>Trends in Prevalence of Gout Among US Asian Adults, 2011-2018 <a href="https://pubmed.ncbi.nlm.nih.gov/37083663/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/37083663/</a></p><p>Rheumatoid Arthritis (RA) <a href="https://emedicine.medscape.com/article/331715-overview" rel="noopener noreferrer">https://emedicine.medscape.com/article/331715-overview</a></p><p>Gout Management in Patients With CKD: A Review <a href="https://pubmed.ncbi.nlm.nih.gov/40609855/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/40609855/</a></p><p>Dietary and Lifestyle-Centered Approach in Gout Care and Prevention <a href="https://pubmed.ncbi.nlm.nih.gov/34196878/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/34196878/</a></p><p>Impact of Alcohol Consumption on Hyperuricemia and Gout: A Systematic Review and Meta-analysis <a href="https://pubmed.ncbi.nlm.nih.gov/40463472/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/40463472/</a></p><p>Beer, Liquor, and Wine Consumption and Serum Uric Acid Level: The Third National Health and Nutrition Examination Survey <a href="https://pubmed.ncbi.nlm.nih.gov/15593346/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/15593346/</a></p><p>Alcohol Consumption as a Trigger of Recurrent Gout Attacks <a href="https://pubmed.ncbi.nlm.nih.gov/16945617/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/16945617/</a></p><p>Effects of Dietary Factors on Hyperuricaemia and Gout: A Systematic Review and Meta-analysis of Observational Studies <a href="https://pubmed.ncbi.nlm.nih.gov/39289820/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/39289820/</a></p><p>Is There a Role for Cherries in the Management of Gout? <a href="https://pubmed.ncbi.nlm.nih.gov/31205513/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/31205513/</a></p><p>Cherry Consumption and Decreased Risk for Recurrent Gout Attacks <a href="https://pubmed.ncbi.nlm.nih.gov/23023818/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/23023818/</a></p><p>Lowering and Raising Serum Urate Levels: Off-Label Effects of Commonly Used Medications <a href="https://pubmed.ncbi.nlm.nih.gov/35787862/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/35787862/</a></p><p>Environmental Triggers of Hyperuricemia and Gout <a href="https://pubmed.ncbi.nlm.nih.gov/36333002/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/36333002/</a></p><p>Elevated Blood Lead Levels Associated With Illicitly Distilled Alcohol—Alabama, 1990-1991 <a href="https://pubmed.ncbi.nlm.nih.gov/1565093/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/1565093/</a></p><p>SGLT2 Inhibitors vs Sulfonylureas for Gout Prevention Among Patients With Type 2 Diabetes Receiving Metformin <a href="https://pubmed.ncbi.nlm.nih.gov/38619822/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/38619822/</a></p><p>Newer Glucose-Lowering Drugs and Risk for Gout: A Network Meta-Analysis of Randomized Outcomes Trials <a href="https://pubmed.ncbi.nlm.nih.gov/38796335/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/38796335/</a></p><p>Asymptomatic Hyperuricemia. Risks and Consequences in the Normative Aging Study <a href="https://pubmed.ncbi.nlm.nih.gov/3826098/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/3826098/</a></p><p>Serum Urate and Recurrent Gout <a href="https://pubmed.ncbi.nlm.nih.gov/38319333/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/38319333/</a></p><p>Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients With Gout <a href="https://pubmed.ncbi.nlm.nih.gov/35916846/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/35916846/</a></p><p>Cardiovascular Safety of Febuxostat or Allopurinol in Patients With Gout <a href="https://pubmed.ncbi.nlm.nih.gov/29527974/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/29527974/</a></p><p>Trends in Gout and Rheumatoid Arthritis Hospitalizations in the United States, 1993-2011 <a href="https://pubmed.ncbi.nlm.nih.gov/27272587/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/27272587/</a></p><p>The Design of a Randomized Controlled Active Comparator Strategy Trial for Gout: Treat to Target Serum Urate Vs Treat to Avoid Symptoms <a href="https://pubmed.ncbi.nlm.nih.gov/40126890/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/40126890/</a></p><br/> <p>Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.</p>]]></content:encoded>
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      <itunes:title>Why Is Gout on the Rise?</itunes:title>
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      <title>Seeing Gout Clearly: Advances in Diagnosis and Imaging</title>
      <description><![CDATA[<p>Drs Kenneth Saag and Nicola Dalbeth explore how crystal analysis and imaging advances can sharpen gout diagnosis and guide patient care.</p>
<p>Relevant disclosures can be found with the episode show notes on Medscape <a href="https://www.medscape.com/ca8/p04/podcast-gout-s1-ep2-2026a1000qej" rel="noopener noreferrer">https://www.medscape.com/ca8/p04/podcast-gout-s1-ep2-2026a1000qej</a>. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.</p>
<p><strong>Resources</strong></p>
<p>Gout and Pseudogout <a href="https://emedicine.medscape.com/article/329958-overview" rel="noopener noreferrer">https://emedicine.medscape.com/article/329958-overview</a></p>
<p>2015 Gout Classification Criteria: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative <a href="https://pubmed.ncbi.nlm.nih.gov/26352873/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/26352873/</a></p>
<p>Clinical Features and Recurrent Attack in Gout Patients According to Serum Urate Levels During an Acute Attack <a href="https://pubmed.ncbi.nlm.nih.gov/30685959/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/30685959/</a></p>
<p>Gout on the Acute Medical Take <a href="https://pubmed.ncbi.nlm.nih.gov/40436276/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/40436276/</a></p>
<p>Psoriatic Arthritis <a href="https://emedicine.medscape.com/article/2196539-overview" rel="noopener noreferrer">https://emedicine.medscape.com/article/2196539-overview</a></p>
<p>Rheumatoid Arthritis (RA) <a href="https://emedicine.medscape.com/article/331715-overview" rel="noopener noreferrer">https://emedicine.medscape.com/article/331715-overview</a></p>
<p>Synovial Fluid Analysis: Relevance for Daily Clinical Practice <a href="https://pubmed.ncbi.nlm.nih.gov/37429800/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/37429800/</a></p>
<p>Advanced Imaging Techniques in Crystal Arthritis <a href="https://pubmed.ncbi.nlm.nih.gov/39906218/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/39906218/</a></p>
<p>Ultrasound Features in Gout: An Overview <a href="https://pubmed.ncbi.nlm.nih.gov/39189200/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/39189200/</a></p>
<p>Dynamic Assessment of the Double Contour Sign by Ultrasonography Helps to Distinguish Between Gout and Calcium Pyrophosphate Deposition Disease <a href="https://pubmed.ncbi.nlm.nih.gov/36927850/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/36927850/</a></p>
<p>Test Characteristics of Raman Spectroscopy Integrated With Polarized Light Microscopy for the Diagnosis of Acute Gouty Arthritis <a href="https://pubmed.ncbi.nlm.nih.gov/37442334/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/37442334/</a></p>
<p>Dual-energy CT Applications in Musculoskeletal Disorders <a href="https://pubmed.ncbi.nlm.nih.gov/38291893/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/38291893/</a></p><br/> <p>Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.</p>]]></description>
      <pubDate>Wed, 2 Sep 2026 13:43:31 +0000</pubDate>
      <author>medscapepodcasts@webmd.net (Dr Kenneth Saag, Dr Nicola Dalbeth)</author>
      <link>https://www.medscape.com/ca8/p04/podcast-gout-s1-ep2-2026a1000qej</link>
      <content:encoded><![CDATA[<p>Drs Kenneth Saag and Nicola Dalbeth explore how crystal analysis and imaging advances can sharpen gout diagnosis and guide patient care.</p>
<p>Relevant disclosures can be found with the episode show notes on Medscape <a href="https://www.medscape.com/ca8/p04/podcast-gout-s1-ep2-2026a1000qej" rel="noopener noreferrer">https://www.medscape.com/ca8/p04/podcast-gout-s1-ep2-2026a1000qej</a>. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.</p>
<p><strong>Resources</strong></p>
<p>Gout and Pseudogout <a href="https://emedicine.medscape.com/article/329958-overview" rel="noopener noreferrer">https://emedicine.medscape.com/article/329958-overview</a></p>
<p>2015 Gout Classification Criteria: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative <a href="https://pubmed.ncbi.nlm.nih.gov/26352873/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/26352873/</a></p>
<p>Clinical Features and Recurrent Attack in Gout Patients According to Serum Urate Levels During an Acute Attack <a href="https://pubmed.ncbi.nlm.nih.gov/30685959/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/30685959/</a></p>
<p>Gout on the Acute Medical Take <a href="https://pubmed.ncbi.nlm.nih.gov/40436276/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/40436276/</a></p>
<p>Psoriatic Arthritis <a href="https://emedicine.medscape.com/article/2196539-overview" rel="noopener noreferrer">https://emedicine.medscape.com/article/2196539-overview</a></p>
<p>Rheumatoid Arthritis (RA) <a href="https://emedicine.medscape.com/article/331715-overview" rel="noopener noreferrer">https://emedicine.medscape.com/article/331715-overview</a></p>
<p>Synovial Fluid Analysis: Relevance for Daily Clinical Practice <a href="https://pubmed.ncbi.nlm.nih.gov/37429800/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/37429800/</a></p>
<p>Advanced Imaging Techniques in Crystal Arthritis <a href="https://pubmed.ncbi.nlm.nih.gov/39906218/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/39906218/</a></p>
<p>Ultrasound Features in Gout: An Overview <a href="https://pubmed.ncbi.nlm.nih.gov/39189200/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/39189200/</a></p>
<p>Dynamic Assessment of the Double Contour Sign by Ultrasonography Helps to Distinguish Between Gout and Calcium Pyrophosphate Deposition Disease <a href="https://pubmed.ncbi.nlm.nih.gov/36927850/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/36927850/</a></p>
<p>Test Characteristics of Raman Spectroscopy Integrated With Polarized Light Microscopy for the Diagnosis of Acute Gouty Arthritis <a href="https://pubmed.ncbi.nlm.nih.gov/37442334/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/37442334/</a></p>
<p>Dual-energy CT Applications in Musculoskeletal Disorders <a href="https://pubmed.ncbi.nlm.nih.gov/38291893/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/38291893/</a></p><br/> <p>Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.</p>]]></content:encoded>
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      <title>Gout and Comorbidities: A Two-Way Relationship</title>
      <description><![CDATA[<p>Drs Ken Saag and Michael Pillinger explore the chicken-or-egg question connecting gout with cardiovascular, kidney, and metabolic conditions.</p>
<p>Relevant disclosures can be found with the episode show notes on Medscape <a href="https://www.medscape.com/ca8/p04/podcast-gout-s1-ep1-2026a1000qeh" rel="noopener noreferrer">https://www.medscape.com/ca8/p04/podcast-gout-s1-ep1-2026a1000qeh</a>. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.</p>
<p><strong>Resources</strong></p>
<p>Gout and Pseudogout <a href="https://emedicine.medscape.com/article/329958-overview" rel="noopener noreferrer">https://emedicine.medscape.com/article/329958-overview</a></p>
<p>Gout: Global Epidemiology, Risk Factors, Comorbidities and Complications: A Narrative Review <a href="https://pubmed.ncbi.nlm.nih.gov/39702222/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/39702222/</a></p>
<p>The Fifth Element: Is Vascular Dysfunction an Intrinsic Feature of Gout? <a href="https://pubmed.ncbi.nlm.nih.gov/40021439/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/40021439/</a></p>
<p>Hyperuricemia Induces a Primary Renal Arteriolopathy in Rats by a Blood Pressure-Independent Mechanism <a href="https://pubmed.ncbi.nlm.nih.gov/11997315/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/11997315/</a></p>
<p>The Environment and Disease: Association or Causation? <a href="https://pubmed.ncbi.nlm.nih.gov/14283879/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/14283879/</a></p>
<p>Effect of Allopurinol on Blood Pressure of Adolescents With Newly Diagnosed Essential Hypertension: A Randomized Trial <a href="https://pubmed.ncbi.nlm.nih.gov/18728266/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/18728266/</a></p>
<p>Expert Consensus and Evidence-Based Recommendations for the Assessment of Flow-Mediated Dilation in Humans <a href="https://pubmed.ncbi.nlm.nih.gov/31211361/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/31211361/</a></p>
<p>Reading Mendelian Randomisation Studies: A Guide, Glossary, and Checklist for Clinicians <a href="https://pubmed.ncbi.nlm.nih.gov/30002074/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/30002074/</a></p>
<p>Effects of Allopurinol on the Progression of Chronic Kidney Disease <a href="https://pubmed.ncbi.nlm.nih.gov/32579811/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/32579811/</a></p>
<p>Pegloticase Treatment Significantly Decreases Blood Pressure in Patients With Chronic Gout <a href="https://pubmed.ncbi.nlm.nih.gov/31079535/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/31079535/</a></p>
<p>Treat-to-Target Urate-Lowering Treatment and Cardiovascular Outcomes in Patients With Gout <a href="https://pubmed.ncbi.nlm.nih.gov/41587055/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/41587055/</a></p>
<p>Risk of Venous Thromboembolism With Gout Flares <a href="https://pubmed.ncbi.nlm.nih.gov/36808284/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/36808284/</a></p>
<p>Cardiovascular Events in Patients With Gout Initiating Urate-Lowering Therapy With or Without Colchicine for Flare Prophylaxis: A Retrospective New-User Cohort Study Using Linked Primary Care, Hospitalisation, and Mortality Data <a href="https://pubmed.ncbi.nlm.nih.gov/39708831/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/39708831/</a></p>
<p>Comparative Cardiovascular Safety of Nonsteroidal Anti-Inflammatory Drug Versus Colchicine Use When Initiating Urate-Lowering Therapy Among Patients With Gout: Target Trial Emulations <a href="https://pubmed.ncbi.nlm.nih.gov/40415645/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/40415645/</a></p>
<p>Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease - Japanese Guideline on the Management of Asymptomatic Hyperuricemia <a href="https://pubmed.ncbi.nlm.nih.gov/33342914/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/33342914/</a></p><br/> <p>Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.</p>]]></description>
      <pubDate>Wed, 2 Sep 2026 13:42:22 +0000</pubDate>
      <author>medscapepodcasts@webmd.net (Dr Kenneth Saag, Dr Michael H. Pillinger)</author>
      <link>https://www.medscape.com/ca8/p04/podcast-gout-s1-ep1-2026a1000qeh</link>
      <content:encoded><![CDATA[<p>Drs Ken Saag and Michael Pillinger explore the chicken-or-egg question connecting gout with cardiovascular, kidney, and metabolic conditions.</p>
<p>Relevant disclosures can be found with the episode show notes on Medscape <a href="https://www.medscape.com/ca8/p04/podcast-gout-s1-ep1-2026a1000qeh" rel="noopener noreferrer">https://www.medscape.com/ca8/p04/podcast-gout-s1-ep1-2026a1000qeh</a>. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.</p>
<p><strong>Resources</strong></p>
<p>Gout and Pseudogout <a href="https://emedicine.medscape.com/article/329958-overview" rel="noopener noreferrer">https://emedicine.medscape.com/article/329958-overview</a></p>
<p>Gout: Global Epidemiology, Risk Factors, Comorbidities and Complications: A Narrative Review <a href="https://pubmed.ncbi.nlm.nih.gov/39702222/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/39702222/</a></p>
<p>The Fifth Element: Is Vascular Dysfunction an Intrinsic Feature of Gout? <a href="https://pubmed.ncbi.nlm.nih.gov/40021439/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/40021439/</a></p>
<p>Hyperuricemia Induces a Primary Renal Arteriolopathy in Rats by a Blood Pressure-Independent Mechanism <a href="https://pubmed.ncbi.nlm.nih.gov/11997315/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/11997315/</a></p>
<p>The Environment and Disease: Association or Causation? <a href="https://pubmed.ncbi.nlm.nih.gov/14283879/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/14283879/</a></p>
<p>Effect of Allopurinol on Blood Pressure of Adolescents With Newly Diagnosed Essential Hypertension: A Randomized Trial <a href="https://pubmed.ncbi.nlm.nih.gov/18728266/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/18728266/</a></p>
<p>Expert Consensus and Evidence-Based Recommendations for the Assessment of Flow-Mediated Dilation in Humans <a href="https://pubmed.ncbi.nlm.nih.gov/31211361/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/31211361/</a></p>
<p>Reading Mendelian Randomisation Studies: A Guide, Glossary, and Checklist for Clinicians <a href="https://pubmed.ncbi.nlm.nih.gov/30002074/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/30002074/</a></p>
<p>Effects of Allopurinol on the Progression of Chronic Kidney Disease <a href="https://pubmed.ncbi.nlm.nih.gov/32579811/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/32579811/</a></p>
<p>Pegloticase Treatment Significantly Decreases Blood Pressure in Patients With Chronic Gout <a href="https://pubmed.ncbi.nlm.nih.gov/31079535/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/31079535/</a></p>
<p>Treat-to-Target Urate-Lowering Treatment and Cardiovascular Outcomes in Patients With Gout <a href="https://pubmed.ncbi.nlm.nih.gov/41587055/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/41587055/</a></p>
<p>Risk of Venous Thromboembolism With Gout Flares <a href="https://pubmed.ncbi.nlm.nih.gov/36808284/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/36808284/</a></p>
<p>Cardiovascular Events in Patients With Gout Initiating Urate-Lowering Therapy With or Without Colchicine for Flare Prophylaxis: A Retrospective New-User Cohort Study Using Linked Primary Care, Hospitalisation, and Mortality Data <a href="https://pubmed.ncbi.nlm.nih.gov/39708831/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/39708831/</a></p>
<p>Comparative Cardiovascular Safety of Nonsteroidal Anti-Inflammatory Drug Versus Colchicine Use When Initiating Urate-Lowering Therapy Among Patients With Gout: Target Trial Emulations <a href="https://pubmed.ncbi.nlm.nih.gov/40415645/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/40415645/</a></p>
<p>Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease - Japanese Guideline on the Management of Asymptomatic Hyperuricemia <a href="https://pubmed.ncbi.nlm.nih.gov/33342914/" rel="noopener noreferrer">https://pubmed.ncbi.nlm.nih.gov/33342914/</a></p><br/> <p>Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.</p>]]></content:encoded>
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