This podcast is intended for healthcare professionals only

Sunshine: An Exploration of Living When You Are Dying https://www.penguinrandomhouse.com/books/822950/sunshine-by-bryant-lin-md/

MED275 - A Doctor’s Journey with Lung Cancer

https://www.youtube.com/playlist?list=PLuP5qOnCjJ-5lMaHJsGAAIN2xtc-8R0DB

Three Hopes and a Dream: Bryant Lin Keynote Address | 2025 Stanford School of Medicine Graduation

https://www.youtube.com/watch?v=ogVjD2WS6qk

Stuck@Home concerts https://www.youtube.com/watch?v=Bd0BIZVTB5w

Don’t fall for these myths on prior authorization

https://www.ama-assn.org/practice-management/prior-authorization/don-t-fall-these-myths-prior-authorization

White House drafting executive order to take over NIH grant approvals: Reports

https://thehill.com/policy/healthcare/6102144-executive-order-nih-grantmaking/

Lou Gehrig, The Luckiest Man https://baseballhall.org/discover-more/stories/baseball-history/lou-gehrig-luckiest-man

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Hear John Mandrola, MD’s summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic

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Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington

Is a Long-Simmering Crisis Boiling Over? U.S. Primary Care Today

https://doi.org/10.1056/NEJMms2510425

The Global Wellness Economy Hits a Record $6.8 Trillion and Is Forecast to Reach $9.8 Trillion by 2029 https://globalwellnessinstitute.org/press-room/press-releases/the-global-wellness-economy-hits-a-record-6-8-trillion-and-is-forecast-to-reach-9-8-trillion-by-2029/

Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association

https://doi.org/10.1161/CIR.0000000000001078

Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)17018-9/abstract

Here's What We Know

https://weillcornell.org/heres-what-we-know

Fifth Circuit sides with ivermectin-prescribing doctors in their quarrel with the FDA https://www.courthousenews.com/fifth-circuit-sides-with-ivermectin-prescribing-doctors-in-their-quarrel-with-the-fda/

SNAP Tracker: People Are Losing Food Assistance as the Republican Megabill Is Implemented https://www.cbpp.org/research/food-assistance/snap-tracker-people-are-losing-food-assistance-as-the-republican-megabill

Chronic Conditions and Food Insecurity in US Children https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2839376

As Unregulated Peptides Flood the Market, Clinicians Encouraged to Counsel Patients https://www.medscape.com/viewarticle/unregulated-peptides-flood-market-clinicians-encouraged-2026a1000e63

Coethia

https://coethia.com/

You may also like:

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact news@medscape.net

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington

Taking Our Medicine — Improving Adherence in the Accountability Era

https://doi.org/10.1056/NEJMp1307084

Full Coverage for Preventive Medications after Myocardial Infarction (MI FREEE trial)

https://doi.org/10.1056/NEJMsa11079

Dr Rosenbaum's Not Otherwise Specified Podcast

https://not-otherwise-specified-podcast.nejm.org/

The Concierge Cure?

https://doi.org/10.1056/NEJMms2510427

Medical Education in the United States and Canada – Flexner

https://doi.org/10.1126/science.32.810.41

The Importance of Being – Abraham Verghese

https://doi.org/10.1377/hlthaff.2016.0837

Evidence-Based Medicine

https://doi.org/10.1136/bmj.312.7023.71

You may also like:

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact news@medscape.net

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington

A Giant Leap. How AI Is Transforming Healthcare and What That Means for Our Future

https://www.penguinrandomhouse.com/books/776443/a-giant-leap-by-robert-wachter-md/

Revisiting the Time Needed to Provide Adult Primary Care

https://doi.org/10.1007/s11606-022-07707-x

Bob Wachter, Digital Doctor Author, Interviewed

https://www.medscape.com/viewarticle/848172

Evidence based medicine: what it is and what it isn't

https://doi.org/10.1136/bmj.312.7023.71

Your A.I. Radiologist Will Not Be With You Soon

https://www.nytimes.com/2025/05/14/technology/ai-jobs-radiologists-mayo-clinic.html

What This Computer Needs Is a Physician: Humanism and Artificial Intelligence https://doi.org/10.1001/jama.2017.19198

Reliability of LLMs as medical assistants for the general public: a randomized preregistered study

https://doi.org/10.1038/s41591-025-04074-y

Expressing stigma and inappropriate responses prevents LLMs from safely replacing mental health providers

https://arxiv.org/abs/2504.18412

Perceptions and Opinions of Patients About Mental Health Chatbots: Scoping Review

https://doi.org/10.2196/17828

User Intentions to Use ChatGPT for Self-Diagnosis and Health-Related Purposes: Cross-sectional Survey Study

https://doi.org/10.2196/47564

KFF Health Misinformation Tracking Poll: Artificial Intelligence and Health Information

https://www.kff.org/public-opinion/kff-health-misinformation-tracking-poll-artificial-intelligence-and-health-information/

You may also like:

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact news@medscape.net

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington

Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association https://www.ahajournals.org/doi/10.1161/CIR.0000000000001078

Migraine Headache: An Under-Appreciated Risk Factor for Cardiovascular Disease in Women https://www.ahajournals.org/doi/10.1161/JAHA.119.014546

Cardiovascular disease patients have increased risk for comorbidity: A cross-sectional study in the Netherlands

https://doi.org/10.1080/13814788.2017.1398318

Characteristics and treatment of midlife-onset epilepsy: A 24-year single-center, retrospective study

https://doi.org/10.1002/epd2.20253

Traumatic Brain Injury and Risk of Neurodegenerative Disorder

https://doi.org/10.1016/j.biopsych.2021.05.025

Cardiac Changes in Parkinson's Disease: Lessons from Clinical and Experimental Evidence

https://doi.org/10.3390/ijms222413488

The neuropathological diagnosis of Alzheimer's disease

https://doi.org/10.1186/s13024-019-0333-5

Failed Semaglutide for Early Alzheimer's Not the End of the Road?

https://www.medscape.com/viewarticle/failed-semaglutide-early-alzheimers-not-end-road-2025a1000y4l

Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration

https://doi.org/10.1161/circulationaha.121.055018

Reduced regional cerebral blood flow in patients with heart failure

https://doi.org/10.1002/ejhf.874

Heart-brain Interactions in Heart Failure

https://doi.org/10.15420/cfr.2018.14.2

While You Were Sleeping, the Brain's 'Waste Disposal System' Was at Work

https://www.medscape.com/viewarticle/while-you-were-sleeping-brains-waste-disposal-system-was-2025a1000mbb

Repurposing Semaglutide and Liraglutide for Alcohol Use Disorder

https://doi.org/10.1001/jamapsychiatry.2024.3599

2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines https://www.ahajournals.org/doi/10.1161/CIR.0000000000001356

"VOODOO" Death https://ajph.aphapublications.org/doi/full/10.2105/AJPH.92.10.1593

Longitudinal brain ageing after stroke: a marker for neurodegeneration and its relevance for upper limb motor outcome https://doi.org/10.1093/braincomms/fcaf299

Unlocking Longevity: Aging Reimagined https://www.medscape.com/viewarticle/1002241

You may also like:

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

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Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington

New ACS Guidelines

2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes

https://doi.org/10.1161/CIR.0000000000001309

ACS Guideline Chair and Vice-Chair Discussion

https://www.medscape.com/viewarticle/acs-guidelines-2025-key-points-chair-and-vice-chair-2025a100093l

Antiplatelet/Antithrombotic Strategies

Prasugrel Beats Ticagrelor in High-Risk Patients With Diabetes After PCI

https://www.medscape.com/viewarticle/prasugrel-beats-ticagrelor-high-risk-patients-diabetes-after-2025a1000wbt

Early Withdrawal of Aspirin after PCI in Acute Coronary Syndromes (NEO-MINDSET)

https://www.nejm.org/doi/full/10.1056/NEJMoa2507980

Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation (AQUATIC)

https://www.nejm.org/doi/full/10.1056/NEJMoa2507532

Bayesian Machine Learning Model Guiding Iterative, Personalized Anticoagulant Dosing Decision-Making : ENGAGE AF-TIMI 48 Trial Analysis

https://doi.org/10.1016/j.jacadv.2025.102504

Factor XI Inhibitors

Bristol Myers, J&J Stop Blood Clotting Drug Trial After Interim Review

https://www.medscape.com/s/viewarticle/bristol-myers-j-j-stop-blood-clotting-drug-trial-after-2025a1000vqu

Bayer's Asundexian Met Primary Efficacy and Safety Endpoints in Landmark Phase III OCEANIC-STROKE Study in Secondary Stroke Prevention https://www.bayer.com/en/us/news-stories/oceanic-stroke

OAC-Naive Subgroup From OCEANIC-AF Published

https://www.medscape.com/viewarticle/novel-blood-thinner-shows-promise-atrial-fibrillation-2025a10008lz

GLP-1 and Myotrophic Drugs

Lilly's Next-gen Drug Shows Greater Weight Loss Than Zepbound in Late-stage Trial (TRIUMPH-4)

https://www.medscape.com/s/viewarticle/lillys-next-gen-drug-tops-zepbound-weight-loss-late-stage-2025a1000ys1

Amylin Analog Eloralintide Reduces Weight in Phase 2 Trial

https://www.medscape.com/viewarticle/amylin-analog-eloralintide-reduces-weight-phase-2-trial-2025a1000uqf

CRISPR and Lipid Lowering

Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease

https://www.nejm.org/doi/full/10.1056/NEJMoa2504747

Gene Therapy Shows Lipid Improvement but Raises Flags

https://www.medscape.com/viewarticle/gene-therapy-shows-lipid-improvement-raises-flags-2025a1000uzw

Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3

https://www.nejm.org/doi/full/10.1056/NEJMoa2511778

Evolocumab in Patients without a Previous Myocardial Infarction or Stroke (VESALIUS-CV)

https://www.nejm.org/doi/pdf/10.1056/NEJMoa2514428

Prehospital GLP IIb/IIIa

Zalunfiban at First Medical Contact for ST-Elevation Myocardial Infarction (CELEBRATE) https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500268

You may also like:

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology

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Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit

https://www.medscape.com/author/bob-harrington

Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association

https://doi.org/10.1161/CIR.0000000000001078

Development and Validation of the American Heart Association's PREVENT Equations

https://doi.org/10.1161/CIRCULATIONAHA.123.067626

C-Reactive Protein and Cardiovascular Risk Among Women With No Standard Modifiable Risk Factors: Evaluating the 'Smurf-Less but Inflamed'

https://doi.org/10.1093/eurheartj/ehaf658

Mortality in STEMI Patients Without Standard Modifiable Risk Factors: A Sex-Disaggregated Analysis of SWEDEHEART Registry Data

https://doi.org/10.1016/S0140-6736(21)00272-5

Inflammation, Cholesterol, Lipoprotein(a), and 30-Year Cardiovascular Outcomes in Women

https://www.nejm.org/doi/10.1056/NEJMoa2405182

Statins for the 'SMuRFLess But Inflamed': Silent Vascular Inflammation and the Challenge of Translational Science

https://doi.org/10.1016/j.jacbts.2025.101318

VERVE-101: A Promising CRISPR-Based Gene Editing Therapy That Reduces LDL-C and PCSK9 Levels in HeFH Patients

https://academic.oup.com/ehjcvp/article/10/2/89/7492807

You may also like:

Hear John Mandrola, MD, give a summary and his perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact news@medscape.net

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington

Super Agers: An Evidence-Based Approach to Longevity

https://www.simonandschuster.com/books/Super-Agers/Eric-Topol/9781668067666

Wellderly study

https://www.scripps.edu/science-and-medicine/translational-institute/translational-research/genomic-medicine/wellderly/

Lotte Bjerre Knudsen

https://erictopol.substack.com/p/lotte-bjerre-knudsen-the-scientist

Organ aging signatures in the plasma proteome track health and disease

https://doi.org/10.1038/s41586-023-

Deep Medicine

https://drerictopol.com/portfolio/deep-medicine/

You may also like:

Hear John Mandrola, MD, give a summary and his perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact news@medscape.net

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit:

https://www.medscape.com/author/bob-harrington

Nobel Prize in Physiology or Medicine 2021

https://pubmed.ncbi.nlm.nih.gov/39429349/

https://www.nobelprize.org/prizes/medicine/2021/press-release/

Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels https://pubmed.ncbi.nlm.nih.gov/20813920/

PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex

https://doi.org/10.1126/science.aau6324

PIEZO Ion Channels in Cardiovascular Functions and Diseases

https://doi.org/10.1161/CIRCRESAHA.123.322798

You may also like:

Hear John Mandrola, MD, with his summary and perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact

news@medscape.net

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington

You may also like:

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic

Questions or feedback, please contact news@medscape.net

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit

https://www.medscape.com/author/bob-harrington

New Cardiology Board Denied but 'Not Done With This Fight' https://www.medscape.com/viewarticle/new-cardiology-board-denied-not-done-this-fight-2025a10006j8

You may also like:

Hear Dr John Mandrola's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic

Questions or feedback, please contact news@medscape.net

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This podcast is intended for healthcare professionals only.

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INCLUDE URLS and full titles for some of the pertinent studies cited.

You may also like:

Principles for the Future of Biomedical Research in the United States and Optimizing the National Institutes of Health: A Presidential Advisory From the American Heart Association

https://doi.org/10.1161/cir.0000000000001319

The Role of Public-Sector Research in the Discovery of Drugs and Vaccines."

https://www.nejm.org/doi/full/10.1056/NEJMsa1008268

Comparison of Research Spending on New Drug Approvals by the National Institutes of Health vs the Pharmaceutical Industry, 2010-2019

https://pubmed.ncbi.nlm.nih.gov/37115539/

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact news@medscape.net

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment https://www.medscape.com/author/bob-harrington

Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction (REDUCE AMI) https://www.nejm.org/doi/abs/10.1056/NEJMoa2401479

Intensive Blood-Pressure Control in Patients with Type 2 Diabetes (BPROAD) https://doi.org/10.1056/nejmoa2412006

Transcatheter Aortic-Valve Replacement for Asymptomatic Severe Aortic Stenosis EARLY TAVR https://www.nejm.org/doi/full/10.1056/NEJMoa2405880

Asundexian versus Apixaban in Patients with Atrial Fibrillation (OCEANIC-AF) https://doi.org/10.1056/NEJMoa2407105

In the Wake of OCEANIC-AF, Is Equipoise Regarding Factor XI Inhibition Still Afloat? https://www.jacc.org/doi/10.1016/j.jacc.2024.10.105

Preventive percutaneous coronary intervention versus optimal medical therapy alone for the treatment of vulnerable atherosclerotic coronary plaques (PREVENT): a multicentre, open-label, randomised controlled trial https://doi.org/10.1016/S0140-6736(24)00413-6

Preventive Coronary Stents: Not There Yet

https://www.medscape.com/viewarticle/preventive-coronary-stents-not-there-yet-2024a10006yr

Speech by Commissioner Robert M. Califf to the House of Medicine June 16, 2023

https://www.fda.gov/news-events/speeches-fda-officials/speech-commissioner-robert-m-califf-house-medicine-06162023

Evolution of Single-Lead ECG for STEMI Detection Using a Deep Learning Approach

https://doi.org/10.1016/j.ijcard.2021.11.039

From ST-Segment Elevation MI to Occlusion MI: The New Paradigm Shift in Acute Myocardial Infarction https://doi.org/10.1016/j.jacadv.2024.101314

You may also like:

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact news@medscape.net

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington

From ST-Segment Elevation MI to Occlusion MI: The New Paradigm Shift in Acute Myocardial Infarction https://doi.org/10.1016/j.jacadv.2024.101314

Angiographic and Clinical Outcomes Among Patients With Acute Coronary Syndromes Presenting With Isolated Anterior ST-Segment Depression: A TRITON-TIMI 38 Substudy https://doi.org/10.1016/j.jcin.2010.05.012

Treatment Time and In-Hospital Mortality Among Patients With ST-Segment Elevation Myocardial Infarction, 2018-2021 https://jamanetwork.com/journals/jama/fullarticle/2798440

Evolution of Single-Lead ECG for STEMI Detection Using a Deep Learning Approach https://doi.org/10.1016/j.ijcard.2021.11.039

Implantable Cardiac Alert System for Early Recognition of ST-Segment Elevation Myocardial Infarction https://doi.org/10.1016/j.jacc.2019.01.014

TIME Trial: Effect of Timing of Stem Cell Delivery Following ST-Elevation Myocardial Infarction on the Recovery of Global and Regional Left Ventricular Function: Final 2-Year Analysis https://doi.org/10.1161/CIRCRESAHA.117.311466

Early Versus Delayed Invasive Intervention in Acute Coronary Syndromes https://www.nejm.org/doi/full/10.1056/NEJMoa0807986

Translating AI for the Clinician https://doi.org/10.1001/jama.2024.21772

A Novel Breakthrough in Wrist-Worn Transdermal Troponin-I-Sensor Assessment for Acute Myocardial Infarction https://doi.org/10.1093/ehjdh/ztad015

A Phase 3 Study of Zalunfiban in Subjects With ST-elevation MI (CELEBRATE) https://clinicaltrials.gov/study/NCT04825743

Selatogrel Outcome Study in Suspected Acute Myocardial Infarction (SOS-AMI) https://clinicaltrials.gov/study/NCT04957719

You may also like:

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic

Questions or feedback, please contact news@medscape.net

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington

From ST-Segment Elevation MI to Occlusion MI: The New Paradigm Shift in Acute Myocardial Infarction https://doi.org/10.1016/j.jacadv.2024.101314

Angiographic and Clinical Outcomes Among Patients With Acute Coronary Syndromes Presenting With Isolated Anterior ST-Segment Depression: A TRITON-TIMI 38 Substudy https://doi.org/10.1016/j.jcin.2010.05.012

Treatment Time and In-Hospital Mortality Among Patients With ST-Segment Elevation Myocardial Infarction, 2018-2021 https://jamanetwork.com/journals/jama/fullarticle/2798440

Evolution of Single-Lead ECG for STEMI Detection Using a Deep Learning Approach https://doi.org/10.1016/j.ijcard.2021.11.039

Implantable Cardiac Alert System for Early Recognition of ST-Segment Elevation Myocardial Infarction https://doi.org/10.1016/j.jacc.2019.01.014

TIME Trial: Effect of Timing of Stem Cell Delivery Following ST-Elevation Myocardial Infarction on the Recovery of Global and Regional Left Ventricular Function: Final 2-Year Analysis https://doi.org/10.1161/CIRCRESAHA.117.311466

Early Versus Delayed Invasive Intervention in Acute Coronary Syndromes https://www.nejm.org/doi/full/10.1056/NEJMoa0807986

Translating AI for the Clinician https://doi.org/10.1001/jama.2024.21772

A Novel Breakthrough in Wrist-Worn Transdermal Troponin-I-Sensor Assessment for Acute Myocardial Infarction https://doi.org/10.1093/ehjdh/ztad015

A Phase 3 Study of Zalunfiban in Subjects With ST-elevation MI (CELEBRATE) https://clinicaltrials.gov/study/NCT04825743

Selatogrel Outcome Study in Suspected Acute Myocardial Infarction (SOS-AMI) https://clinicaltrials.gov/study/NCT04957719

You may also like:

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic

Questions or feedback, please contact news@medscape.net

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington

INCLUDE URLS and full titles for some of the pertinent studies cited.

Forecasting the Burden of Cardiovascular Disease and Stroke in the United States Through 2050

https://doi.org/10.1161/CIR.0000000000001256

Forecasting the Economic Burden of Cardiovascular Disease and Stroke in the United States Through 2050

https://doi.org/10.1161/CIR.0000000000001258

Calculating the 30-day Survival Rate in Acute Myocardial Infarction: Should we Use the Treatment Chain or the Hospital Catchment Model?

https://doi.org/10.5301/heartint.5000238

Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health

https://doi.org/10.1161/CIR.0000000000001078

Current Trends in Hypertension Identification and Management: Insights from the National Health and Nutrition Examination Survey

https://doi.org/10.1161/JAHA.123.034322

Youth-Onset Type 2 Diabetes: The Epidemiology of an Awakening Epidemic

https://doi.org/10.2337/dci22-0046

US Trends in Cholesterol Screening, Lipid Levels, and Lipid‐Lowering Medication Use in US Adults, 1999 to 2018

https://doi.org/10.1161/JAHA.122.028205

GLP-1 Receptor Agonist Discontinuation Among Patients With Obesity and/or Type 2 Diabetes

https://pubmed.ncbi.nlm.nih.gov/38787563

Health Care by Food

https://healthcarexfood.org/

You may also like:

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact

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The Leap Year Gene of Kit McKinley

https://shelleywood.ca/the-leap-year-gene/

Tragedy and Hope Wrapped in a Medical Mystery: Abraham Verghese and The Covenant of Water https://www.medscape.com/viewarticle/991751

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Private Equity Acquisitions of Outpatient Cardiology Practices in the United States, 2013-2023

https://doi.org/10.1016/j.jacc.2024.06.011

Private Equity in Cardiovascular Practice: Solution or Symptom?

https://doi.org/10.1016/j.jacc.2024.06.012

Evaluating Trends in Private Equity Ownership and Impacts on Health Outcomes, Costs, and Quality: Systematic Review

https://doi.org/10.1136/bmj-2023-075244

2020 American Heart Association and American College of Cardiology Consensus Conference on Professionalism and Ethics: A Consensus Conference Report

https://doi.org/10.1161/CIR.0000000000000963

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Health Care by Food Initiative https://healthcarexfood.org/

2021 Dietary Guidance to Improve Cardiovascular Health: A Scientific Statement From the American Heart Association https://doi.org/10.1161/CIR.0000000000001031

Rockefeller Foundation Food is Medicine https://www.rockefellerfoundation.org/initiative/food-is-medicine/

Targeted Scientific Research Projects to Demonstrate Effectiveness of 'Food Is Medicine' in Health Care https://newsroom.heart.org/news/targeted-scientific-research-projects-to-demonstrate-effectiveness-of-food-is-medicine-in-health-care

Food Is Medicine: A Presidential Advisory From the American Heart Association https://doi.org/10.1161/CIR.0000000000001182

Medically Tailored Meal Delivery for Diabetes Patients With Food Insecurity: a Randomized Cross-over Trial https://doi.org/10.1007/s11606-018-4716-z

'Food Is Medicine' Strategies for Nutrition Security and Cardiometabolic Health Equity: JACC State-of-the-Art Review https://doi.org/10.1016/j.jacc.2023.12.023

Current Landscape of Produce Prescription Programs in the US https://doi.org/10.1016/j.jneb.2022.02.011

Behavioral Nudges Are Used Widely to Steer Clinicians and Patients Alike https://doi.org/10.1056/CAT.23.0125

A Primary Care Agenda for Brain Health: A Scientific Statement From the American Heart Association https://www.ahajournals.org/doi/10.1161/STR.0000000000000367#

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Fight Heart Disease Like Cancer https://www.press.jhu.edu/books/title/12793/fight-heart-disease-cancer

PREVENT: AHA's New Risk Calculator Incorporates CKM Health https://www.medscape.com/viewarticle/998679

Artificial intelligence-enabled retinal vasculometry for prediction of circulatory mortality, myocardial infarction and stroke https://doi.org/10.1136/bjo-2022-321842

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Academic Cardiology and Social Media https://doi.org/10.1161/CIRCOUTCOMES.118.004736

Bringing the Credibility Revolution to Observational Research and Cardiology https://doi.org/10.1161/CIRCULATIONAHA.123.064645

Cardio Twitter: An Essential Tool for Staying Current https://www.medscape.com/viewarticle/897512

Identification of Causal Effects Using Instrumental Variables https://doi.org/10.2307/2291629

Explaining Charter School Effectiveness https://www.aeaweb.org/articles?id=10.1257/app.5.4.1

Methods of Public Health Research - Strengthening Causal Inference from Observational Data https://doi.org/10.1056/NEJMp2113319

Publish or Perish and the Incentive for Quantity over Quality Research Papers https://www.medscape.com/viewarticle/998417

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With Great Power Comes Great Responsibility

Big Data Research From the National Inpatient Sample https://doi.org/10.1161/CIRCOUTCOMES.117.003846

Adherence to Methodological Standards in Research Using the National Inpatient Sample

https://doi.org/10.1001/jama.2017.17653

Publish or Perish: Where are we heading?

https://pubmed.ncbi.nlm.nih.gov/24778659

The Kardashian Index of Cardiologists: Celebrities or Experts? https://doi.org/10.1016/j.jaccas.2019.11.068

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Cardiovascular Organizations Pursue New, Independent Medical Board

https://www.acc.org/About-ACC/Press-Releases/2023/09/21/15/02/Cardiovascular-Organizations-Pursue-New-Independent-Medical-Board

The National Board of Physicians and Surgeons

https://nbpas.org/

Level of Scientific Evidence Underlying the Current American College of Cardiology/American Heart Association Clinical Practice Guidelines

https://doi.org/10.1161/CIRCOUTCOMES.118.005293

Validation of a Speech Analysis Application to Detect Worsening Heart Failure Events in Ambulatory Heart Failure Patients https://www.abstractsonline.com/pp8/?_ga=2.17782015.7532578.1693882428-1949139275.1663003561#!/10871/presentation/16568

A systematic review shows no performance benefit of machine learning over logistic regression for clinical prediction models

https://doi.org/10.1016/j.jclinepi.2019.02.004

Recognizing a ruler instead of a cancer

https://menloml.com/2020/01/11/recognizing-a-ruler-instead-of-a-cancer/

The Geographic Bias in Medical AI Tools

https://hai.stanford.edu/news/geographic-bias-medical-ai-tools

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ACC 2023 Top Trials

- Bempedoic Acid Cuts CV Events in Statin-Intolerant Patients: CLEAR Outcomes https://www.medscape.com/viewarticle/989100

- Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients

- Phase 2b Randomized Trial of the Oral PCSK9 Inhibitor MK-0616 https://www.jacc.org/doi/10.1016/j.jacc.2023.02.018

ACC/WCC 2023 Collection Page https://www.medscape.com/viewcollection/36966

ESC 2023 Top Trials

- Wegovy Scores HFpEF Benefits in People With Obesity https://www.medscape.com/viewarticle/995844

- Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity https://www.nejm.org/doi/full/10.1056/NEJMoa2306963

- Acoramidis Shows Encouraging Results in ATTR Cardiomyopathy https://www.medscape.com/viewarticle/995883

ESC 2023 Collection Page https://www.medscape.com/viewcollection/36988

AHA 2023 Top Trials

- Semaglutide 'A New Pathway' to CVD Risk Reduction: SELECT https://www.medscape.com/viewarticle/998373

- Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes https://www.nejm.org/doi/full/10.1056/NEJMoa2307563

- Bariatric Surgery is Associated With Improved Coronary Microvascular Function and Cardiorespiratory Fitness in Patients With Ischemia and Non-Obstructive Coronary Arteries https://www.ahajournals.org/doi/10.1161/circ.148.suppl_1.18949

- Angioplasty Finally Proven Beneficial in Stable Angina: ORBITA-2 https://www.medscape.com/s/viewarticle/998375

- A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina https://www.nejm.org/doi/full/10.1056/NEJMoa2310610

- Impressive Bleeding Profile With Factor XI Inhibitor in AF: AZALEA https://www.medscape.com/viewarticle/998418

- Promising First Results With DNA Editing to Lower LDL https://www.medscape.com/s/viewarticle/998719

- Single Injection Reduces Blood Pressure for 6 Months: KARDIA-1 https://www.medscape.com/viewarticle/998666

AHA 2023 Collection Page https://www.medscape.com/viewcollection/37277

Other Mentions

- N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects https://www.nejm.org/doi/full/10.1056/NEJMc2031173

- Rimonabant: From RIO to Ban https://doi.org/10.1155%2F2011%2F432607

- Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial https://doi.org/10.1016/S0140-6736(17)32714-9

- Asundexian Phase 3 AF Study Halted for Lack of Efficacy https://www.medscape.com/viewarticle/998665

- Challenges in the Design and Interpretation of Noninferiority Trials https://www.nejm.org/doi/full/10.1056/nejmra1510063

- Milvexian for the Prevention of Venous Thromboembolism https://www.nejm.org/doi/full/10.1056/NEJMoa2113194

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https://www.medscape.com/twic

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COVID and the Athlete's Heart

https://www.medscape.com/viewarticle/945282

Outcomes Registry for Cardiac Conditions in Athletes

https://doi.org/10.1161/JAHA.122.029052

2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy

https://doi.org/10.1161/CIR.0000000000000937

Point-of-care screening for HFrEF using artificial intelligence during ECG-enabled stethoscope examination

https://doi.org/10.1016/s2589-7500(21)00256-9

International recommendations for electrocardiographic interpretation in athletes

https://doi.org/10.1093/eurheartj/ehw631

Elevation of Cardiac Troponins After Endurance Running Competitions

https://doi.org/10.1161/CIRCULATIONAHA.118.034655

Vigorous Exercise in Patients With Hypertrophic Cardiomyopathy

https://doi.org/10.1001/jamacardio.2023.1042

Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Preamble, Principles, and General Considerations

https://doi.org/10.1161/CIR.0000000000000236

RACE-CARS Trial

https://racecarstrial.org/

AHA CPR Resources

https://cpr.heart.org/en/cpr-courses-and-kits/hands-only-cpr

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Questions or feedback, please contact news@medscape.net

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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Future Care: Sensors, Artificial Intelligence, and the Reinvention of Medicine. https://www.jagsinghmd.com/book

COVID-19 Hits Physician Couple: Dramatically Different Responses

https://www.medscape.com/viewarticle/928530

Smartwatch Electrocardiogram and Artificial Intelligence for Assessing Cardiac-Rhythm Safety of Drug Therapy in the COVID-19 Pandemic. The QT-logs study

https://doi.org/10.1016/j.ijcard.2021.01.002

The Care of the Patient

https://doi.org/10.1001/jama.1927.02680380001001

Advancements and future directions in the teamwork, targets, technology, and tight control-the 4T study: improving clinical outcomes in newly diagnosed pediatric type 1 diabetes

https://doi.org/10.1097/mop.0000000000001140

Social determinants of telemedicine utilization in ambulatory cardiovascular patients during the COVID-19 pandemic

https://doi.org/10.1093/ehjdh/ztab039

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https://www.medscape.com/twic

Questions or feedback, please contact: news@medscape.net

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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'One Brave Idea' Recipient on Predicting Who Will Develop CAD

https://www.medscape.com/viewarticle/874536

Multinational Federated Learning Approach to Train ECG and Echocardiogram Models for Hypertrophic Cardiomyopathy Detection

https://doi.org/10.1161/circulationaha.121.058696

Application of Artificial Intelligence to the Electrocardiogram

https://doi.org/10.1093/eurheartj/ehab649

Using Machine Learning to Detect Problems in ECG Data Collection

https://www.cinc.org/archives/2011/pdf/0437.pdf

Age and Sex Estimation Using Artificial Intelligence From Standard 12-Lead ECGs

https://doi.org/10.1161/CIRCEP.119.007284

External Validation of a Widely Implemented Proprietary Sepsis Prediction Model in Hospitalized Patients

http://jamanetwork.com/article.aspx?doi=10.1001/jamainternmed.2021.2626

Sepsis Predictor Tool Falls Short in

Emergency Setting

https://www.medscape.com/viewarticle/982534

Dissecting Racial Bias in an Algorithm Used to Manage the Health of Populations

https://doi.org/10.1126/science.aax2342

Geographic Distribution of US Cohorts Used to Train Deep Learning Algorithms https://jamanetwork.com/journals/jama/fullarticle/2770833

Can Medical Algorithms Be Fair? Three Ethical Quandaries and One Dilemma

https://doi.org/10.1136/bmjhci-2021-100445

Healthcare Machine Learning: Getting Started

https://medium.com/@jeninej/healthcare-machine-learning-getting-started-761a7dbb63a2

What Clinicians Should Know About Healthcare AI, Part 1: Why Care About AI?

https://medium.com/@jeninej/what-clinicians-should-know-about-healthcare-ai-part-1-why-care-about-ai-aba6a06f696d

AI in Healthcare Specialization

https://www.coursera.org/specializations/ai-healthcare

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Hear John Mandrola, MD's, summary and perspective on the top cardiology news each week, on This Week in Cardiology: https://www.medscape.com/twic

Questions or feedback, please contact: news@medscape.net

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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Jeff Bezos - Regret Minimization https://www.youtube.com/watch?v=-qPii5ACVYw

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Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine

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https://www.medscape.com/twic

Questions or feedback, please contact

news@medscape.net

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Lipid Lowering

Safety, Tolerability and Efficacy of Up-Titration of Guideline-Directed Medical Therapies for Acute Heart Failure (STRONG-HF): A Multinational, Open-Label, Randomised, Trial

https://doi.org/10.1016/S0140-6736(22)02076-1

Why Combination Lipid-Lowering Therapy Should Be Considered Early in the Treatment of Elevated LDL-C for CV Risk Reduction

https://www.acc.org/latest-in-cardiology/articles/2022/06/01/12/11/why-combination-lipid-lowering-therapy-should-be-considered

Incidental Coronary Artery Calcium: Opportunistic Screening of Prior Non-gated Chest CTs to Improve Statin Rates (NOTIFY-1 Project)

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.062746

Equivalent Impact of Elevated Lipoprotein(a) and Familial Hypercholesterolemia in Patients With Atherosclerotic Cardiovascular Disease

https://doi.org/10.1016/j.jacc.2022.09.021

Comparative Effects of Low-Dose Rosuvastatin, Placebo and Dietary Supplements on Lipids and Inflammatory Biomarkers

https://doi.org/10.1016/j.jacc.2022.10.013

Antihypertensive Drugs

No Survival Advantage for Either Torsemide or Furosemide in HF: TRANSFORM-HF

https://www.medscape.com/viewarticle/983611

Chlorthalidone vs. Hydrochlorothiazide for Hypertension–Cardiovascular Events

www.nejm.org/doi/full/10.1056/NEJMoa2212270

Antiplatelets

Duration of Antiplatelet Therapy After Complex Percutaneous Coronary Intervention in Patients at High Bleeding Risk: A MASTER DAPT Trial Sub-analysis

https://doi.org/10.1093/eurheartj/ehac284

PANTHER: Should Clopidogrel Become the 'New Aspirin' in CAD?

https://www.medscape.com/viewarticle/980117

P2Y12 Inhibitor Versus Aspirin Monotherapy for Secondary Prevention of Cardiovascular Events: Meta-analysis of Randomized Trials

https://doi.org/10.1093/ehjopen/oeac019

Ticagrelor Versus Clopidogrel in Patients With Acute Coronary Syndromes

https://doi.org/10.1056/nejmoa0904327

TCT-320 Pharmacokinetic and Pharmacodynamic Profile of PL-ASA, a Novel Phospholipid-Aspirin Complex Liquid Formulation, Compared to Enteric-Coated Aspirin at an 81-mg Dose – Results From a Prospective, Randomized, Crossover Study

https://www.jacc.org/doi/10.1016/j.jacc.2021.09.1173

Pharmacokinetic and Pharmacodynamic Profile of a Novel Phospholipid Aspirin Formulation

https://europepmc.org/article/pmc/pmc8773391

Antithrombins/Factor XI

Rivaroxaban in Patients With a Recent Acute Coronary Syndrome

https://www.nejm.org/doi/full/10.1056/nejmoa1112277

Genetically Determined FXI (Factor XI) Levels and Risk of Stroke

https://doi.org/10.1161/strokeaha.118.022792

Factor XIa Inhibition With Asundexian After Acute Non-cardioembolic Ischaemic Stroke (PACIFIC-Stroke): an International, Randomised, Double-Blind, Placebo-Controlled, Phase 2b Trial

https://doi.org/10.1016/s0140-6736(22)01588-4

Safety of the Oral Factor Xia Inhibitor Asundexian Compared With Apixaban in Patients With Atrial Fibrillation (PACIFIC-AF): a Multicentre, Randomised, Double-Blind, Double-Dummy, Dose-Finding Phase 2 Study

https://doi.org/10.1016/S0140-6736(22)00456-1

A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction

https://doi.org/10.1161/circulationaha.122.061612

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Questions or feedback? Please contact

news@medscape.net

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit

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COVID Therapies

Therapeutic Anticoagulation With Heparin in Noncritically Ill Patients With Covid-19

https://www.nejm.org/doi/full/10.1056/NEJMoa2105911

Effect of Intermediate/High Versus Low Dose Heparin on the Thromboembolic and Hemorrhagic Risk of Unvaccinated COVID-19 Patients in the Emergency Department

https://doi.org/10.1186/s12873-022-00668-8

Two Old Meds and a DOAC a Bust Across Range of COVID Severity: The ACT Trials

https://www.medscape.com/viewarticle/980049

Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial

http://jamanetwork.com/article.aspx?doi=10.1001/jama.2022.18590

FDA Halts Use of Some COVID Monoclonal Antibodies Due to Omicron

https://www.medscape.com/viewarticle/967210

CT Surgeons Rise to Challenge, Lead Way in COVID Clinical Trials

https://www.sts.org/publications/sts-news/ct-surgeons-rise-challenge-lead-way-covid-clinical-trials

What Do We Know About Long COVID: A Cardiovascular Focus

https://www.medscape.com/viewarticle/981435

COVID-19 and the Heart: Is Cardiology Ready?

https://www.medscape.com/viewarticle/969206

The Stanford RECOVER Trial

https://recovercovid.org/

The Heroes Study

https://heroesresearch.org/

Artificial Intelligence

Age and Sex Estimation Using Artificial Intelligence From Standard 12-Lead ECGs

https://doi.org/10.1161/CIRCEP.119.007284

The Heartline Study

https://www.heartline.com/about

Evolution of Single-Lead ECG for STEMI Detection Using a Deep Learning Approach

https://doi.org/10.1016/j.ijcard.2021.11.039

Recognizing a Ruler Instead of a Cancer

https://menloml.com/2020/01/11/recognizing-a-ruler-instead-of-a-cancer/

Machine Learning Did Not Beat Logistic Regression in Time Series Prediction for Severe Asthma Exacerbations

https://doi.org/10.1038/s41598-022-24909-9

A Systematic Review Shows No Performance Benefit of Machine Learning Over Logistic Regression for Clinical Prediction Models

https://doi.org/10.1016/j.jclinepi.2019.02.004.

Multinational Federated Learning Approach to Train ECG and Echocardiogram Models for Hypertrophic Cardiomyopathy Detection

https://doi.org/10.1161/circulationaha.121.058696

Detection of Hypertrophic Cardiomyopathy Using a Convolutional Neural Network-Enabled Electrocardiogram

https://doi.org/10.1016/j.jacc.2019.12.030

Here's Why We're Not Prepared for the Next Wave of Biotech Innovation (by Matthew Herper)

https://www.statnews.com/2022/11/03/why-were-not-prepared-for-next-wave-of-biotech-innovation/

RCTs from China

Bivalirudin Plus a High-Dose Infusion Versus Heparin Monotherapy in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Randomised Trial

https://doi.org/10.1016/S0140-6736(22)01999-7

Chinese Herbal Medicine May Offer Benefits in STEMI: CTS-AMI

https://www.medscape.com/viewarticle/983619

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Questions or feedback? Please contact

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Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit

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Medium-term Effects of SARS-CoV-2 Infection on Multiple Vital Organs, Exercise Capacity, Cognition, Quality of Life and Mental Health, Post-Hospital Discharge

https://doi.org/10.1016/j.eclinm.2020.100683

Prevalence and Impact of Myocardial Injury in Patients Hospitalized With COVID-19 Infection

https://doi.org/10.1016%2Fj.jacc.2020.06.007

Outcomes Among Confirmed Cases and a Matched Comparison Group in the Long-COVID in Scotland Study https://doi.org/10.1038/s41467-022-33415-5

Long COVID: Post-Acute Sequelae of COVID-19 With a Cardiovascular Focus

https://doi.org/10.1093/eurheartj/ehac031

Cardiovascular Disease and COVID-19: A Consensus Paper From the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in Collaboration With the European Heart Rhythm Association (EHRA)

https://doi.org/10.1093/cvr/cvab298

Infection of Brain Pericytes Underlying Neuropathology of COVID-19 Patients

https://doi.org/10.3390/ijms222111622

COVID-19 and Fat Embolism: A Hypothesis to Explain the Severe Clinical Outcome in people With Obesity

https://pubmed.ncbi.nlm.nih.gov/32514077

Association Between Epstein-Barr-Virus Reactivation and Development of Long-COVID Fatigue

https://doi.org/10.1111/all.15471

Activation or Exhaustion of CD8+ T Cells in Patients With COVID-19

https://doi.org/10.1038/s41423-021-00750-4

Skeletal Muscle Alterations in Patients With Acute COVID-19 and Post-Acute Sequelae of COVID-19

https://doi.org/10.1002/jcsm.12896

Gut Microbiota Dynamics in a Prospective Cohort of Patients With Post-Acute COVID-19 Syndrome

http://dx.doi.org/10.1136/gutjnl-2021-325989

COVID-Vaccine Myocarditis: Rare, Mild, and Usually a Guy Thing

https://www.medscape.com/viewarticle/966244

Myocardial Injury Pattern at MRI in COVID-19 Vaccine–Associated Myocarditis

https://doi.org/10.1148/radiol.212559

Could Perturbation of Gut Microbiota Possibly Exacerbate the Severity of COVID-19 via Cytokine Storm?

https://doi.org/10.3389/fimmu.2020.607734

Myocarditis Associated With COVID-19 Vaccination

https://doi.org/10.1161/CIRCIMAGING.121.013236

COVID and the Athlete's Heart

https://www.medscape.com/viewarticle/945282

COVID-19 and the Heart: Is Cardiology Ready?

https://www.medscape.com/viewarticle/969206

Lung Abnormalities Depicted With Hyperpolarized Xenon MRI in Patients With Long COVID

https://doi.org/10.1148/radiol.220069

Long COVID Resource Center

https://www.medscape.com/resource/long-covid

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A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation (AFFIRM)

https://www.nejm.org/doi/full/10.1056/NEJMoa021328

Early Rhythm-Control Therapy in Patients with Atrial Fibrillation (EAST-AFNET 4)

https://www.nejm.org/doi/10.1056/NEJMoa2019422

Early AF Rhythm-Control Advantage Climbs With Comorbidity Burden: EAST-AFNET4

https://www.medscape.com/viewarticle/979627

Early Dronedarone Versus Usual Care to Improve Outcomes in Persons With Newly Diagnosed Atrial Fibrillation (CHANGE-AFIB)

https://clinicaltrials.gov/ct2/show/NCT05130268

Generalizability of the EAST‐AFNET 4 Trial: Assessing Outcomes of Early Rhythm‐Control Therapy in Patients With Atrial Fibrillation

https://doi.org/10.1161/JAHA.121.024214

Early Rhythm Control Therapy for Atrial Fibrillation in Low-Risk Patients

A Nationwide Propensity Score–Weighted Study

https://doi.org/10.7326/M21-4798

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https://www.medscape.com/twic

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The ABC Updates its CV DIBS Rankings | Association of Black Cardiologists

https://abcardio.org/recent-news/the-abc-updates-its-cv-dibs-rankings/

FDA Takes Important Steps to Increase Racial and Ethnic Diversity in Clinical Trials

https://www.fda.gov/news-events/press-announcements/fda-takes-important-steps-increase-racial-and-ethnic-diversity-clinical-trials

Gender Diversity in Cardiovascular Clinical Trial Research Begins at the Top

https://www.jacc.org/doi/abs/10.1016/j.jacc.2022.01.001

A Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops

https://www.nejm.org/doi/full/10.1056/NEJMoa1717250

At Black Barbershops, BP Reductions Still in Style at 1 Year

https://www.medscape.com/viewarticle/906724

Physician-Patient Racial Concordance and Disparities in Birthing Mortality for Newborns

https://doi.org/10.1073/pnas.1913405117

Racial and Ethnic Diversity at Medical Schools -- Why Aren't We There Yet?

https://www.nejm.org/doi/full/10.1056/NEJMp2105578

Medical School Enrollment More Diverse in 2021

https://www.aamc.org/news-insights/press-releases/medical-school-enrollment-more-diverse-2021#r

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https://www.medscape.com/twic

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How Medical Education Is Missing the Bull's-eye

https://doi.org/10.1056/NEJMp1915891

This Is What I Want To Tell My White Professors When They Ask, 'How Are You Today?'

https://www.huffpost.com/entry/black-medical-student-wants-white-professors-to-know_n_5ed91238c5b6e0feefc26315

Statue of Controversial Surgeon to Be Moved From Central Park

https://www.medscape.com/viewarticle/891413

A Rift Over Carl Linnaeus Shows We Shouldn't Idolise Scientists

https://science.thewire.in/the-sciences/carl-linnaeus-entomological-society-of-america-great-man-theory-progress/

Running Away from Drapetomania: Samuel A. Cartwright, Medicine, and Race in the Antebellum South

https://muse.jhu.edu/article/699875

What Led Chicago to Shutter Dozens of Majority-Black Schools? Racism

https://www.theguardian.com/us-news/2018/dec/06/chicago-public-schools-closures-racism-ghosts-in-the-schoolyard-extract

Call to Action: Structural Racism as a Fundamental Driver of Health Disparities: A Presidential Advisory From the American Heart Association

https://doi.org/10.1161/CIR.0000000000000936

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https://www.medscape.com/twic

Questions or feedback, please contact: news@medscape.net

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2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization

https://doi.org/10.1016/j.jacc.2021.09.006

Evidence Based Medicine: What It Is and What It Isn't

https://doi.org/10.1136/bmj.312.7023.71

2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease:

https://doi.org/10.1161/CIR.0000000000000404

Ticagrelor With or Without Aspirin in High-Risk Patients After PCI

https://doi.org/10.1056/NEJMoa1908419

Surgical Groups Push Back Against New Revascularization Guidelines

https://www.medscape.com/viewarticle/966153

Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity

https://doi.org/10.1161/CIRCULATIONAHA.120.049755

The Invisible Hand — Medical Care During the Pandemic

https://www.nejm.org/doi/full/10.1056/NEJMp2006607

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https://www.medscape.com/twic

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Robert A. Harrington, MD, Arthur L. Bloomfield Professor; Chair, Department of Medicine, Stanford University; Chair, Department of Medicine, Stanford Medical Center, Stanford, California

Ziyad Al-Aly, MD, Chief of Research and Development, VA St. Louis Health Care System, St. Louis, Missouri

COVID-19 and Long-term Health

Long-Term Cardiovascular Outcomes of COVID-19 https://doi.org/10.1038/s41591-022-01689-3

High-Dimensional Characterization of Post-acute Sequelae of COVID-19

https://doi.org/10.1038/s41586-021-03553-9

Risks of Mental Health Outcomes in People With COVID-19: Cohort Study

https://doi.org/10.1136/bmj-2021-068993

Kidney Outcomes in Long COVID

https://doi.org/10.1681/ASN.2021060734

I'm 26. Coronavirus Sent Me to the Hospital.

https://www.nytimes.com/2020/03/23/opinion/coronavirus-young-people.html

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https://www.medscape.com/twic

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news@medscape.net

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CV Public Health Trials

Interim effects of salt substitution on urinary electrolytes and blood pressure in the China Salt Substitute and Stroke Study (SSaSS) https://doi.org/10.1016/j.ahj.2019.12.020

A Cluster Randomized Trial of a Village Doctor-Led Intervention on Blood Pressure Control: China Rural Hypertension Control Project

https://www.abstractsonline.com/pp8/?_ga=2.141042993.2042594723.1635046736-1021258137.1633710264#!/9349/presentation/18155

A Remotely Delivered Hypertension and Lipid Program in 10,000 Patients Across a Diverse Health Care Network

https://www.abstractsonline.com/pp8/?_ga=2.141042993.2042594723.1635046736-1021258137.1633710264#!/9349/presentation/18153

COVID-19 Public Health Trials

Impact of community masking on COVID-19: A cluster-randomized trial in Bangladesh

https://www.poverty-action.org/publication/impact-community-masking-covid-19-cluster-randomized-trial-bangladesh

Dexamethasone in Hospitalized Patients with Covid-19

https://doi.org/10.1056/NEJMoa2021436

Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19

https://jamanetwork.com/journals/jama/fullarticle/2775280

The Recovery Trial Initiative

https://www.recoverytrial.net/results

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https://www.medscape.com/twic

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Antiplatelet Therapy

Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease

https://doi.org/10.1056/NEJMoa2102137

Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk

https://doi.org/10.1056/NEJMoa2108749

Effect of 1-Month Dual Antiplatelet Therapy Followed by Clopidogrel vs 12-Month Dual Antiplatelet Therapy on Cardiovascular and Bleeding Events in Patients Receiving PCI

https://doi.org/10.1001/jama.2019.8145

Aspirin Versus Clopidogrel for Chronic Maintenance Monotherapy After Percutaneous Coronary Intervention (HOST-EXAM): An Investigator-Initiated, Prospective, Randomised, Open-Label, Multicentre Trial

https://doi.org/10.1016/S0140-6736(21)01063-1

SGLT2 Inhibitors and GLP-1 Agonists

Empagliflozin in Heart Failure with a Preserved Ejection Fraction

https://www.nejm.org/doi/full/10.1056/NEJMoa2107038

Once-Weekly Semaglutide in Adults with Overweight or Obesity

https://www.nejm.org/doi/full/10.1056/NEJMoa2032183

Cardiac Surgery and PCI

Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke

https://doi.org/10.1056/NEJMoa2101897

Concomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation

https://doi.org/10.1056/NEJMoa2115961

Fractional Flow Reserve–Guided PCI as Compared with Coronary Bypass Surgery

https://doi.org/10.1056/NEJMoa2112299

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https://www.medscape.com/twic

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The Bob Harrington Show is intended for healthcare professionals.

RECOVERY Trial Website and Some Publications

Randomized Evaluation of COVID-19 Therapy

https://www.recoverytrial.net/

Dexamethasone in Hospitalized Patients with Covid-19

https://www.nejm.org/doi/full/10.1056/nejmoa2021436

Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

https://doi.org/10.1016/S0140-6736(20)32013-4

Remdesivir for the Treatment of Covid-19 — Final Report https://www.nejm.org/doi/full/10.1056/nejmoa2007764

Dexamethasone in Hospitalized Patients with Covid-19 https://www.nejm.org/doi/full/10.1056/nejmoa2021436

Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19

https://www.nejm.org/doi/full/10.1056/NEJMoa2022926

Clinical Trials and Informed Consent

The good Clinical Trials Collaborative

https://www.goodtrials.org/

Why do we need some large, simple randomized trials?

https://doi.org/10.1002/sim.4780030421

Assessment of Length and Readability of Informed Consent Documents for COVID-19 Vaccine Trials

http://jamanetwork.com/article.aspx?doi=10.1001/jamanetworkopen.2021.10843

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https://www.medscape.com/twic

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The Book

The Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Them https://us.macmillan.com/books/9781250234995

The People

Stephen Quake

Clinical assessment incorporating a personal genome https://doi.org/10.1016/s0140-6736(10)60452-7

Leilani Graham https://www.leilanirgraham.com/

Eero Mäntyranta https://theolympians.co/2018/01/22/eero-mantyranta-the-ruddy-cheeks-and-the-genetic-advantange-of-a-cross-country-skiing-legend-from-finland/

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Medscape Editor-in-Chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine

Hear Dr John Mandrola's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic

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Early Studies

Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19) https://doi.org/10.1001/jamacardio.2020.3557

Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection https://doi.org/10.1001/jamacardio.2020.4916

Pooled autopsy https://www.medscape.com/viewarticle/944496

Pathological Evidence for SARS-CoV-2 as a Cause of Myocarditis: JACC Review Topic of the Week

https://doi.org/10.1016/j.jacc.2020.11.031

Lake Louise Criteria https://pubmed.ncbi.nlm.nih.gov/30545455/

Recognition and Initial Management of Fulminant Myocarditis

A Scientific Statement From the American Heart Association

https://doi.org/10.1161/CIR.0000000000000745

Long-Haul Post–COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrome: The Swedish Experience

https://doi.org/10.1016/j.jaccas.2021.01.009

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https://www.medscape.com/twic

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