https://simplecast.com Investigating HLH Investigating HLH, brought to you by Sobi Inc., is a podcast that takes a deep dive into the complex world of hemophagocytic lymphohistiocytosis, or HLH. As a rare and fatal disease that was once considered incurable, HLH presents with a range of severe signs and symptoms that make diagnosis difficult. Join us as we discuss insights about HLH from all angles with various experts in the field of hematology-oncology who have helped to advance the understanding and treatment of this devastating disease. When treating patients with HLH, knowledge is power—because knowing what to look for can save lives. 2023 Sobi Inc. en Tue, 23 Sep 2025 04:00:00 +0000 Thu, 16 Jul 2026 16:53:26 +0000 https://investigating-hlh.simplecast.com Investigating HLH https://image.simplecastcdn.com/images/28a945fd-e1b5-4c16-b0ea-459c23b33a88/6d988ca5-2e09-4b1e-9526-a4c6be57ce4b/3000x3000/podcast-album-cover-for-amazelabs-3000x3000.jpg?aid=rss_feed https://investigating-hlh.simplecast.com episodic Investigating HLH, brought to you by Sobi Inc., is a podcast that takes a deep dive into the complex world of hemophagocytic lymphohistiocytosis, or HLH. As a rare and fatal disease that was once considered incurable, HLH presents with a range of severe signs and symptoms that make diagnosis difficult. Join us as we discuss insights about HLH from all angles with various experts in the field of hematology-oncology who have helped to advance the understanding and treatment of this devastating disease. When treating patients with HLH, knowledge is power—because knowing what to look for can save lives. Sobi Inc. false https://feeds.simplecast.com/HCYrlxBB sobi inc. Sobi Inc. stories@amazemedialabs.com 7c0f5730-8847-4476-a604-ecd6f5a5fa6d What Is Macrophage Activation Syndrome (MAS)? Adam Narloch speaks with Dr Randy Cron and Dr Daniella Schwartz about the pathology of macrophage activation syndrome (MAS), including its pathophysiology and relationship to hemophagocytic lymphohistiocytosis (HLH). This discussion addresses why MAS recognition can be clinically challenging and how clinicians may think about MAS in the context of hyperinflammation and rheumatologic disease.

This video features expert clinician discussion and is intended for US healthcare professionals.

Chapters

0:00 - What Is Macrophage Activation Syndrome (MAS)?

5:21 - MAS as a Form of Hemophagocytic Lymphohistiocytosis (HLH)

10:12 - Clinical Outcomes and Urgency in MAS

11:09 - Relationship Between MAS and HLH

18:02 - Diagnosing MAS: Criteria, Workup, and Differential Diagnosis

25:53 - Key Takeaways for MAS Recognition and Diagnosis

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https://www.sobi.com/usa/en

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]]> Tue, 23 Sep 2025 04:00:00 +0000 stories@amazemedialabs.com (Dr. Daniella Schwartz, Dr. Randy Cron, Adam Narloch) https://investigating-hlh.simplecast.com/episodes/what-is-mas-QcI03qv3 Adam Narloch speaks with Dr Randy Cron and Dr Daniella Schwartz about the pathology of macrophage activation syndrome (MAS), including its pathophysiology and relationship to hemophagocytic lymphohistiocytosis (HLH). This discussion addresses why MAS recognition can be clinically challenging and how clinicians may think about MAS in the context of hyperinflammation and rheumatologic disease.

This video features expert clinician discussion and is intended for US healthcare professionals.

Chapters

0:00 - What Is Macrophage Activation Syndrome (MAS)?

5:21 - MAS as a Form of Hemophagocytic Lymphohistiocytosis (HLH)

10:12 - Clinical Outcomes and Urgency in MAS

11:09 - Relationship Between MAS and HLH

18:02 - Diagnosing MAS: Criteria, Workup, and Differential Diagnosis

25:53 - Key Takeaways for MAS Recognition and Diagnosis

Follow Us

Presented by Sobi Inc.

https://www.sobi.com/usa/en

©2023 Sobi, Inc. All rights reserved. NP-32204 12/23 


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]]> What Is Macrophage Activation Syndrome (MAS)? Dr. Daniella Schwartz, Dr. Randy Cron, Adam Narloch 00:29:31 Adam Narloch speaks with Dr Randy Cron and Dr Daniella Schwartz about the pathology of macrophage activation syndrome (MAS), including its pathophysiology and relationship to hemophagocytic lymphohistiocytosis (HLH). Adam Narloch speaks with Dr Randy Cron and Dr Daniella Schwartz about the pathology of macrophage activation syndrome (MAS), including its pathophysiology and relationship to hemophagocytic lymphohistiocytosis (HLH). false full 1 2 3bb78659-b6a5-43ae-a315-00dbd5249fc9 Monitoring Treatment Response Kari Magee speaks with Dr Bethany Verkamp to discuss her research on evaluating treatment response to etoposide-based treatment in patients with hemophagocytic lymphohistiocytosis (HLH). The discussion covers clinical and laboratory considerations for monitoring HLH treatment response, including how clinicians may evaluate response over time while managing HLH in patients.

This video features expert clinician discussion and is intended for US healthcare professionals.

Chapters

0:00 - Monitoring Hemophagocytic Lymphohistiocytosis (HLH) Treatment Response: Study Context

2:07 - Study Design: Evaluating HLH Treatment Response

9:19 - Clinical and Laboratory Response Findings in HLH

11:37 - How HCPs May Monitor Treatment Response in HLH

13:53 - Key Takeaways for HLH Response Monitoring

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https://www.sobi.com/usa/en

©2023 Sobi, Inc. All rights reserved. NP-32204 12/23 


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]]> Tue, 25 Feb 2025 05:00:00 +0000 stories@amazemedialabs.com (Kari Magee, Dr Bethany Verkamp) https://investigating-hlh.simplecast.com/episodes/monitoring-treatment-response-Z5mqG9p9 Kari Magee speaks with Dr Bethany Verkamp to discuss her research on evaluating treatment response to etoposide-based treatment in patients with hemophagocytic lymphohistiocytosis (HLH). The discussion covers clinical and laboratory considerations for monitoring HLH treatment response, including how clinicians may evaluate response over time while managing HLH in patients.

This video features expert clinician discussion and is intended for US healthcare professionals.

Chapters

0:00 - Monitoring Hemophagocytic Lymphohistiocytosis (HLH) Treatment Response: Study Context

2:07 - Study Design: Evaluating HLH Treatment Response

9:19 - Clinical and Laboratory Response Findings in HLH

11:37 - How HCPs May Monitor Treatment Response in HLH

13:53 - Key Takeaways for HLH Response Monitoring

Follow Us

Presented by Sobi Inc.

https://www.sobi.com/usa/en

©2023 Sobi, Inc. All rights reserved. NP-32204 12/23 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

]]> Monitoring Treatment Response Kari Magee, Dr Bethany Verkamp 00:15:53 Kari Magee speaks with Dr Bethany Verkamp to discuss her research on evaluating treatment response to etoposide-based treatment in patients with hemophagocytic lymphohistiocytosis (HLH). Kari Magee speaks with Dr Bethany Verkamp to discuss her research on evaluating treatment response to etoposide-based treatment in patients with hemophagocytic lymphohistiocytosis (HLH). false full 4 1 3ab60d5c-ccd4-4c8c-87c6-902e97ce33d8 Treating Hemophagocytic Lymphohistiocytosis (HLH) Dr Saara Kaviany and Dr Blachy J. Dávila Saldaña discuss the overall treatment goals and management strategies for patients with hemophagocytic lymphohistiocytosis (HLH). The discussion focuses on clinical considerations in HLH management, treatment goals, and factors clinicians may consider when evaluating patients with HLH.

This video features expert clinician discussion and is intended for US healthcare professionals.

Chapters

0:00 - HLH Treatment Goals and Management Overview

5:07 - Primary HLH Treatment Goals: Stabilization, Toxicity Reduction, and HSCT Preparation

10:40 - HSCT in Primary HLH: Treatment Pathway Considerations

18:43 - Initial HLH Treatment and Hyperinflammation Control

24:59 - HLH Treatment Risks and Clinical Considerations

30:01 - Targeted Treatment Approaches in HLH

35:17 - Key Takeaways for HLH Treatment Planning

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]]> Wed, 5 Jun 2024 04:00:00 +0000 stories@amazemedialabs.com (Adam Narloch, Saara Kaviany, Blachy J. Dávila Saldaña) https://investigating-hlh.simplecast.com/episodes/treating-hlh-OQMAoQrW Dr Saara Kaviany and Dr Blachy J. Dávila Saldaña discuss the overall treatment goals and management strategies for patients with hemophagocytic lymphohistiocytosis (HLH). The discussion focuses on clinical considerations in HLH management, treatment goals, and factors clinicians may consider when evaluating patients with HLH.

This video features expert clinician discussion and is intended for US healthcare professionals.

Chapters

0:00 - HLH Treatment Goals and Management Overview

5:07 - Primary HLH Treatment Goals: Stabilization, Toxicity Reduction, and HSCT Preparation

10:40 - HSCT in Primary HLH: Treatment Pathway Considerations

18:43 - Initial HLH Treatment and Hyperinflammation Control

24:59 - HLH Treatment Risks and Clinical Considerations

30:01 - Targeted Treatment Approaches in HLH

35:17 - Key Takeaways for HLH Treatment Planning

Follow Us

Presented by Sobi Inc.

www.sobi.com

©2023 Sobi, Inc. All rights reserved. NP-32204 12/23 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

]]> Treating Hemophagocytic Lymphohistiocytosis (HLH) Adam Narloch, Saara Kaviany, Blachy J. Dávila Saldaña 00:35:38 Dr Saara Kaviany and Dr Blachy J. Dávila Saldaña discuss the overall treatment goals and management strategies for patients with hemophagocytic lymphohistiocytosis (HLH). Dr Saara Kaviany and Dr Blachy J. Dávila Saldaña discuss the overall treatment goals and management strategies for patients with hemophagocytic lymphohistiocytosis (HLH). false full 3 1 e1773aca-9e4f-46af-84e4-1808bb488e1f Diagnosing Hemophagocytic Lymphohistiocytosis (HLH) Adam Narloch speaks with Dr Ashish Kumar and Dr Scott Canna to discuss the challenges involved with diagnosing and managing hemophagocytic lymphohistiocytosis (HLH). The discussion focuses on key considerations in HLH management, treatment goals, and clinical complexities involved in evaluating patients with HLH.

This video features expert clinician discussion and is intended for US healthcare professionals.

Chapters

0:00 - Why HLH Diagnosis Can Be Challenging

4:59 - Why Early and Accurate HLH Diagnosis Matters

10:10 - HLH Diagnostic Criteria and Clinical Workup

25:31 - Genetic Testing and Functional Assays for HLH

37:26 - Biomarkers in HLH Diagnosis: Ferritin, sCD25, and CXCL9

43:00 - HLH Disease Mimics and Differential Diagnosis

54:00 - HLH Guidelines: Limitations and Clinical Judgment

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https://www.sobi.com/usa/en

©2023 Sobi, Inc. All rights reserved. NP-32204 12/23 


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]]> Wed, 15 May 2024 04:00:00 +0000 stories@amazemedialabs.com (Adam Narloch, Ashish Kumar, Scott Canna) https://investigating-hlh.simplecast.com/episodes/diagnosing-hlh-oczCwjrp Adam Narloch speaks with Dr Ashish Kumar and Dr Scott Canna to discuss the challenges involved with diagnosing and managing hemophagocytic lymphohistiocytosis (HLH). The discussion focuses on key considerations in HLH management, treatment goals, and clinical complexities involved in evaluating patients with HLH.

This video features expert clinician discussion and is intended for US healthcare professionals.

Chapters

0:00 - Why HLH Diagnosis Can Be Challenging

4:59 - Why Early and Accurate HLH Diagnosis Matters

10:10 - HLH Diagnostic Criteria and Clinical Workup

25:31 - Genetic Testing and Functional Assays for HLH

37:26 - Biomarkers in HLH Diagnosis: Ferritin, sCD25, and CXCL9

43:00 - HLH Disease Mimics and Differential Diagnosis

54:00 - HLH Guidelines: Limitations and Clinical Judgment

Follow Us

Presented by Sobi Inc.

https://www.sobi.com/usa/en

©2023 Sobi, Inc. All rights reserved. NP-32204 12/23 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

]]> Diagnosing Hemophagocytic Lymphohistiocytosis (HLH) Adam Narloch, Ashish Kumar, Scott Canna 00:53:00 Adam Narloch speaks with Dr Ashish Kumar and Dr Scott Canna to discuss the challenges involved with diagnosing and managing hemophagocytic lymphohistiocytosis (HLH). Adam Narloch speaks with Dr Ashish Kumar and Dr Scott Canna to discuss the challenges involved with diagnosing and managing hemophagocytic lymphohistiocytosis (HLH). false full 2 1 6189a869-08ba-47da-8df5-af96d17d734b An Introduction to Hemophagocytic Lymphohistiocytosis (HLH) Adam Narloch speaks with Dr Michelle Hermiston to discuss the history of hemophagocytic lymphohistiocytosis (HLH), advances in clinical understanding, and why recognition of this rare hyperinflammatory syndrome remains important. Topics include HLH disease awareness, primary and secondary HLH context, clinical recognition, and the evolving understanding of HLH as a serious hyperinflammatory condition.

This video features expert clinician discussion and is intended for US healthcare professionals.

Chapters

0:00 - What Is Hemophagocytic Lymphohistiocytosis (HLH)?

2:19 - How Clinical Understanding of HLH Has Evolved

6:46 - Immune Dysregulation and Hyperinflammation in HLH

10:16 - Interferon Gamma (IFNγ) and Proinflammatory Cytokines in HLH

14:29 - Primary vs Secondary Hemophagocytic Lymphohistiocytosis (HLH)

21:00 - Key Takeaways for HLH Recognition

Follow Us

Presented by Sobi Inc.

https://www.sobi.com/usa/en

©2023 Sobi, Inc. All rights reserved. NP-32204 12/23 


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]]> Mon, 22 Apr 2024 04:00:00 +0000 stories@amazemedialabs.com (Adam Narloch, Michelle Hermiston) https://investigating-hlh.simplecast.com/episodes/introduction-to-hlh-bu4exrhl-cXX__diB Adam Narloch speaks with Dr Michelle Hermiston to discuss the history of hemophagocytic lymphohistiocytosis (HLH), advances in clinical understanding, and why recognition of this rare hyperinflammatory syndrome remains important. Topics include HLH disease awareness, primary and secondary HLH context, clinical recognition, and the evolving understanding of HLH as a serious hyperinflammatory condition.

This video features expert clinician discussion and is intended for US healthcare professionals.

Chapters

0:00 - What Is Hemophagocytic Lymphohistiocytosis (HLH)?

2:19 - How Clinical Understanding of HLH Has Evolved

6:46 - Immune Dysregulation and Hyperinflammation in HLH

10:16 - Interferon Gamma (IFNγ) and Proinflammatory Cytokines in HLH

14:29 - Primary vs Secondary Hemophagocytic Lymphohistiocytosis (HLH)

21:00 - Key Takeaways for HLH Recognition

Follow Us

Presented by Sobi Inc.

https://www.sobi.com/usa/en

©2023 Sobi, Inc. All rights reserved. NP-32204 12/23 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

]]> An Introduction to Hemophagocytic Lymphohistiocytosis (HLH) Adam Narloch, Michelle Hermiston 00:23:00 Adam Narloch speaks with Dr Michelle Hermiston to discuss the history of hemophagocytic lymphohistiocytosis (HLH), advances in clinical understanding, and why recognition of this rare hyperinflammatory syndrome remains important. Adam Narloch speaks with Dr Michelle Hermiston to discuss the history of hemophagocytic lymphohistiocytosis (HLH), advances in clinical understanding, and why recognition of this rare hyperinflammatory syndrome remains important. false full 1 1 90358bb2-12c9-4fa2-b178-341d3ce3118b An Introduction to HLH In this episode of Investigating HLH, Adam Narloch, a Thought Leader Liaison at Sobi, speaks with Dr Michelle Hermiston to discuss the history of HLH and advances that have been made in understanding this rare disease. Dr Hermiston is a pediatric hematologist-oncologist, a bone marrow transplant specialist, and the director of the Pediatric Immunotherapy Program at UCSF Benioff Children’s Hospital. Join us as we start our journey into the world of HLH!

Follow Us

Presented by Sobi Inc.

https://www.sobi.com/usa/en

©2023 Sobi, Inc. All rights reserved. NP-32204 12/23 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

]]> Tue, 14 Nov 2023 18:22:35 +0000 stories@amazemedialabs.com (Adam Narloch, Dr Michelle Hermiston) https://investigating-hlh.simplecast.com/episodes/introduction-to-hlh-nO50NkFJ In this episode of Investigating HLH, Adam Narloch, a Thought Leader Liaison at Sobi, speaks with Dr Michelle Hermiston to discuss the history of HLH and advances that have been made in understanding this rare disease. Dr Hermiston is a pediatric hematologist-oncologist, a bone marrow transplant specialist, and the director of the Pediatric Immunotherapy Program at UCSF Benioff Children’s Hospital. Join us as we start our journey into the world of HLH!

Follow Us

Presented by Sobi Inc.

https://www.sobi.com/usa/en

©2023 Sobi, Inc. All rights reserved. NP-32204 12/23 


Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

]]> An Introduction to HLH Adam Narloch, Dr Michelle Hermiston 00:00:41 Join us with Dr Michelle Hermiston to discuss the history of hemophagocytic lymphohistiocytosis (HLH) and advances in our knowledge of this rare disease. Join us with Dr Michelle Hermiston to discuss the history of hemophagocytic lymphohistiocytosis (HLH) and advances in our knowledge of this rare disease. false trailer 1